目的: 观察He-Ne激光照射联合质子泵抑制剂(PPIs)、胃动力药治疗反流性食管炎(RE)的疗效。方法: 将126 例RE患者随机分为观察组和对照组, 各63例。对照组采用埃索美拉唑、伊托必利治疗; 观察组在对照组基础上实施He-Ne激光照射治疗。比较两组临床疗效及治疗前后临床症状评分、内镜分级积分、食管动力学指标、胃肠激素和胃蛋白酶原水平。结果: 观察组治疗总有效率(92.06%)显著高于对照组(77.78%), 差异有统计学意义(P＜0.05)。经治疗后, 两组烧心、反酸、胸痛等临床症状评分及内镜分级积分均降低(P＜0.05), 但与对照组相比, 观察组以上临床症状评分及内镜分级积分降低更明显(P＜0.05)。治疗后, 两组食管括约肌压力明显增高, 立位反流时间比、卧位反流时间比、总反流时间比明显下降(P＜0.05), 但观察组以上指标与对照组相比改善程度更大(P＜0.05)。与治疗前比较, 两组治疗后GAS、MOT、PG I、PGⅠ/PGⅡ明显增高(P＜0.05), VIP明显下降(P＜0.05), 但观察组改善幅度大于对照组(P＜0.05)。结论: He-Ne激光照射联合PPIs、胃动力药治疗RE的疗效显著, 优于单纯应用PPIs和胃动力药治疗, 能有效改善患者的食管动力学指标及胃肠激素水平。

The stretcher system is an important part in the high-engery petawatt laser facility. The stretcher system design has a direct impact on the quality of the output pulses. The stretcher systems in some famous high-energy petawatt laser facility are summarized. And the structure and parameters are compared and discussed.

The impact of the stretcher on the contrast ratio of the out pulse is analyzed making use of the ray -tracing method , which is based on the contrast ratio model of chirped pulse.When the beam size in the stretcher is increased from 2 mm to 40 mm ,the contrast of the output pulse approximately increase two magnitude. When the input pulse is Sech2 ,the contrast of the output pulse is better than what the input pulse is Gassian or Rectangular.

In the design of the Offner stretcher, it is very important to investigate the mirror curvature radius errors, which has a direct impact on the quality of the output pulse. So it is necessary to analyse the effect on the output pulse contrast due to the mirror curvature radius manufacture errors in the ffner stretcher. A ray-tracing model for ffner stretcher with these errors is established. Based on the model, effects on output pulse contrast through the stretcher is analyzed.When the mirror curvature radius error is between 0.2%～0.5%, it can fully meet the requirements for the SHENGUANG Ⅱ petawatt laser facility. Also, when there is error for the mirror curvature radius, keeping the distance between concave mirror and convex mirror half of curvature radius of the concave mirror is better than keeping the two curve mirrors in the same center.

In a stretcher,it is important of spectral clipping. It has a direct impact on the quality of the output pulse. Base on the ray-tracing,an analytical spectral clipping model is present in the ffner stretcher . When the stretcher parameters is determined, the location of the grating placed has a very important influence on the pulse spectral clipping. When the grating placed on the symmetric center about optical axis, the spectral distribution through stretcher will be asymmetric about center wavelength of the laser, that is to say,the spectral clipping will be asymmetric spectral clipping.Therefore,the output pulse contrast will be droped approximately one magnitude in the SGII ninth beam petawatt upgrade laser facility. In order to keeping the spectral symmetry distribution about center wavelength of the laser through the stretcher, the grating must be placed on the asymmetrical position about optical axis.

Based on the optical activity of quartz crystal, we proposed a scheme for shaping the spatial intensity distribution of a linearly polarized laser beam by utilizing a quartz crystal plano-convex lens in combination with a polarizer. The intensity profile of the shaped laser beam can be easily switched from one profile to another by controlling the polarization direction of the incident laser beam.

Offner展宽器的设计研究中,对曲面镜曲率半径的误差研究非常重要,它直接影响输出脉冲的质量。因此有必要分析ffner展宽器中曲面镜曲率半径的误差对输出脉冲对比度的影响。参考ffner展宽器的光线追迹模型,建立了ffner展宽器中曲面镜曲率半径存在误差时的光线追迹模型; 根据建立的模型,详细分析了曲面镜曲率半径的误差对输出脉冲质量的影响; 发现在目前曲面镜曲率半径的加工误差在0.2%～0.5%的情况下,完全可以满足神光II拍瓦激光装置中对展宽器的要求; 同时发现如果曲面镜曲率半径存在误差时,应该尽量使两曲面镜之间的距离保持为凹面反射镜曲率半径的一半,而不是使两曲面镜保持同心。

在展宽器中,光谱的剪切情况非常重要,它直接影响输出脉冲的质量。以ffner展宽器为例,参照以往建立的光线追迹模型,建立了分析展宽器中光谱剪切的模型。发现当展宽器的参数确定好后,光栅放置的位置对激光脉冲光谱剪切有非常重要的影响。当光栅相对于光轴中心对称放置时,展宽器容许通过的光谱相对于激光中心波长将是非对称分布的,即此时在展宽器中发生的光谱剪切为非对称光谱剪切,在神光II第9路拍瓦激光装置中,这种非对称光谱剪切将使输出脉冲对比度下降一个数量级。为了使展宽器中通过的光谱相对于激光中心波长对称分布,需要将光栅相对于光轴非中心对称放置。

Based on the optical activity of quartz crystal, we proposed a scheme for shaping the spatial intensity distribution of a linearly polarized laser beam by utilizing a quartz crystal plano-convex lens in combination with a polarizer. The intensity profile of the shaped laser beam can be easily switched from one profile to another by controlling the polarization direction of the incident laser beam.

展宽系统是高能拍瓦激光装置中的重要组成部分。它的设计好坏直接影响输出脉冲的质量。综述了国内外著名的高能拍瓦激光装置中所用展宽系统的结构及其相应的参数，并加以比较分析和讨论。